Archive for the ‘science’ Category

The War on Drugs

Thursday, August 15th, 2013

My sentiments on the whole drug question have been influenced by some experience with the medical aspect of the problem. Drugs are slipping out of any control due to developments in synthetic variations of older substances that stimulate brain chemistry, sometimes in unknown ways. The traditional drugs, if we can use that term, are also slipping out of control with Mexican drug wars replacing the Columbian cartels even more violent than their predecessors.

What about marijuana ? It is widely used by the younger generation and, while I do think there are some harmful consequences, especially in potential schizophrenics, the fact is that the laws are widely ignored and do little good and much harm. First, what about the link to psychosis ?

Epidemiological studies suggest that Cannabis use during adolescence confers an increased risk for developing psychotic symptoms later in life. However, despite their interest, the epidemiological data are not conclusive, due to their heterogeneity; thus modeling the adolescent phase in animals is useful for investigating the impact of Cannabis use on deviations of adolescent brain development that might confer a vulnerability to later psychotic disorders. Although scant, preclinical data seem to support the presence of impaired social behaviors, cognitive and sensorimotor gating deficits as well as psychotic-like signs in adult rodents after adolescent cannabinoid exposure, clearly suggesting that this exposure may trigger a complex behavioral phenotype closely resembling a schizophrenia-like disorder. Similar treatments performed at adulthood were not able to produce such phenotype, thus pointing to a vulnerability of the adolescent brain towards cannabinoid exposure.

This suggests that adult use may be less harmful.

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Schizophrenia and civil rights.

Wednesday, December 19th, 2012

In June 1962, I had just finished a year of active duty in the Air Force (actually 9 months) and was looking for a job until I went back to medical school in September. I had been pulled out when the reserves were called up by Kennedy in the wake of the Berlin Wall, built by the Russians in August.

I found an ad in the LA Times for medical students to work at the VA hospital in west Los Angeles. I was a medical student although I had had only one month of medical school. I had, however, been a corpsman in the Air Force so had a little more clinical experience than many first year medical students.

I applied and was accepted. I learned the job was to do annual physical exams on 200 chronic schizophrenics since the psychiatry residents, in the grip of the psychoanalytic phase of psychiatry, did not want to do so. I started about the 15th of June and soon met my boss, a professor of psychiatry at UCLA named George L Harrington.

He was a striking individual, a big man who walked with a pronounced limp from a previous femur fracture. The effect of this combination was powerful on the chronic schizophrenics of Building 206 at the Sawtelle VA Hospital.

Harrington was one of the two or three most impressive men I ever met in medicine. He had trained as an analyst and his father was one of the first lay analysts, a former Baptist minister. Harrington had met Sigmund Freud and actually sat on his knee as a child. He grew up near the Menninger Clinic in Kansas and went to Kansas Medical School. He told me that one of his first summers in medical school, he got a job at the state mental hospital and tried his psychoanalytic theories out on chronic psychotic patients. They didn’t work. When summer was over and the state psychiatrists returned from vacation, they treated one depressed female patient with shock therapy. Harrington had spent the summer trying analysis on her with no success. With one ECT session she was much improved. That was enough to convince him that analysis did not work, no matter that the psychoanalytic school of psychiatry had taken over the specialty and the departments of all the medical schools.

Harrington was sure this was all wrong and was convinced that schizophrenia was an organic disease. He told me that it might even be a deficiency of an unknown vitamin. It wasn’t so many years since beri-beri and pellagra had been discovered to be vitamin deficiencies. I have previously referred to this experience, and I am convinced that he was on the right track when most psychiatrists were wrong.

Unfortunately, the psychiatry profession held on to psychoanalytic thinking far too long. A friend of mine from medical school is an analyst and has made a good living from it in Malibu. That is a good choice of location since analysis works best on rich mildly neurotic patients. Psychotics tend to be poor and difficult to work with. Now, with huge advances in neurobiology there is more hope but the public is still reluctant to trust psychiatrists with any authority. I am afraid that the profession is still suspect from the years of the Freudian blind alley.

A fellow named Clayton Cramer, who has a schizophrenic brother named Ron, has written an excellent book about the legal history of the deinstitutionalization movement that emptied the mental hospitals since 1960. On his blog, he posts that the shooter in Connecticut may have been taking Fanapt, an antipsychotic drug that is prescribed for schizophrenia. A rather hysterical post on what looks like an anti-treatment site alleges that SSRIs, a class of drug that is unrelated to anti-psychotics, are responsible for mass shooting incidents. It is this sort of misinformation that muddies the waters around the issue of violence and mental illness. The drug, iloperidone is an “atypical anti-psychotic” which means it is a serotonin receptor antagonist. It was nothing to do with SSRIs, which are selective serotonin reuptake inhibitors. The effects are very different as are the mechanism.

The battle for intelligent treatment of schizophrenics goes on.

A summary of treatment options does not mention the most serious problem. That is that schizophrenics commonly stop taking the drug, either because they feel fine and believe they no longer need it, or because they have no insight into their condition and refuse the drugs unless coerced. This is the reason why commitment, even outpatient commitment which involves supervision of the drug taking, is desirable.

The Connecticut Massacre

Saturday, December 15th, 2012

There is information still coming to light about this awful case. Early reports, such as the name of the shooter and the alleged murder of the father, were predictably wrong. It turns out that the shooter, named Adam Lanza, a 20 year old with a history of odd behavior and some evidence of mental illness, such as autism, was living with his mother who was his first victim. There are a number of suggestive reports, that she decided to “stay home to care for” her 20 year old son.

The treatment of severe mental illness in this country has been altered for the worse by a movement that began in the 1960s when mental illness began to be described as a “civil rights ” issue. Several books and movies described abuse of power in commitment of the mentally ill. The first such movie was “The Snake Pit” in which a young woman is committed for what sounds like schizophrenia. The treatment of the time (1948) can be seen as barbaric but there was nothing else available. She did recover, although we know that without adequate treatment, recovery from schizophrenia is unlikely.

The movie that really devastated the mental hospital system was called “One Flew Over the Cuckoo’s Nest” and starred Jack Nicholson.

As I type this, a black professor of psychiatry is talking on the TV and discussing gun control !! His mention of mental illness is brief and noncommittal.

The movie was powerful in showing the Nicholson character as a guy who just is “different” and harmless.

The film was the second to win all five major Academy Awards (Best Picture, Actor in Lead Role, Actress in Lead Role, Director, and Screenplay) following It Happened One Night in 1934, an accomplishment not repeated until 1991 by The Silence of the Lambs.

In 1963 Oregon, Randle Patrick “Mac” McMurphy (Jack Nicholson), a recidivist anti-authoritarian criminal serving a short sentence on a prison farm for statutory rape of a 15-year-old girl, is transferred to a mental institution for evaluation. Although he does not show any overt signs of mental illness, he hopes to avoid hard labor and serve the rest of his sentence in a more relaxed hospital environment.
McMurphy’s ward is run by steely, unyielding Nurse Mildred Ratched (Louise Fletcher), who employs subtle humiliation, unpleasant medical treatments and a mind-numbing daily routine to suppress the patients. McMurphy finds that they are more fearful of Ratched than they are focused on becoming functional in the outside world. McMurphy establishes himself immediately as the leader; his fellow patients include Billy Bibbit (Brad Dourif), a nervous, stuttering young man; Charlie Cheswick (Sydney Lassick), a man disposed to childish fits of temper; Martini (Danny DeVito), who is delusional; Dale Harding (William Redfield), a high-strung, well-educated paranoid; Max Taber (Christopher Lloyd), who is belligerent and profane; Jim Sefelt (William Duell); and “Chief” Bromden (Will Sampson), a silent American Indian believed to be deaf and mute.

Here is the picture of mental illness as a matter of civil rights. It was shown in 1975 when the deinstitutionalizing was already well along and it convinced the public, few of whom know anything of psychology, that mental hospitals should be closed. State governors, like Ronald Reagan in California, were only too happy to oblige. This is why I was not a Reagan fan before he was elected in 1980.

The new drugs, like Thorazine made all this possible. Patients on Thorazine made almost miraculous recoveries. at least until the side effects appeared.

The introduction of chlorpromazine into clinical use has been described as the single greatest advance in psychiatric care, dramatically improving the prognosis of patients in psychiatric hospitals worldwide[citation needed]; the availability of antipsychotic drugs curtailed indiscriminate use of electroconvulsive therapy and psychosurgery, and was one of the driving forces behind the deinstitutionalization movement.

Actually ECT or “shock therapy” was, and remains, effective for severe depression. When used on psychotics like schizophrenics, it often provided a period of a “lucid interval” that lasted for hours when the psychosis seemed to relent. The symptoms recurred but the hope of longer intervals resulted in repeated sessions. It was often depicted with convulsions and other horrendous effects but, in reality, anesthesia and muscle relaxants were used to avoid such scenes. Even insulin coma, which has a risk of damage from low blood glucose, was effective for periods when nothing else worked.

The alternative offered was outpatient centers, in California authorized by The Short-Doyle Act of 1957. There was never enough money and governors saw the closing of state hospitals as a budget issue, not a medical issue.

Throughout the 1970s and 1980s counties contended that the state was not providing adequate funds for community mental health programs. In addition, several counties were receiving less funds on a population basis than other counties. This disparity was addressed, with varying levels of success, in both the 1970s and the 1980s with the allocation of “equity funds” to certain counties. Realignment enacted in 1991 has made new revenues available to local governments for mental health programs, but, according to local mental health administrators, funding has lagged behind demand.

And As a result of declining hospital population, three hospitals (Modesto, DeWitt, and Mendocino) were closed. Legislative intent was to have the budget savings from the closures go to local programs. The “money was to follow the patient.” This did not happen in 1972 and 1973 as a result of the Governor’s veto.

The patients released from state hospitals ended up living in the streets as “the homeless problem” exploded. Others filled the jails. In 2000 I was told by directors of homeless shelters in Los Angeles that 60% of the homeless were psychotic, 60% were drug addicts and half of each group was both. About 10% of the homeless are neither and are quickly moved to shelters and “SRO” hotels, especially if there are children.

What percent of shizophrenics are violent or capable of it ? A national study suggests that the number may be higher than we are usually told.

The 6-month prevalence of any violence was 19.1%, with 3.6% of participants reporting serious violent behavior. Distinct, but overlapping, sets of risk factors were associated with minor and serious violence. “Positive” psychotic symptoms, such as persecutory ideation, increased the risk of minor and serious violence, while “negative” psychotic symptoms, such as social withdrawal, lowered the risk of serious violence. Minor violence was associated with co-occurring substance abuse and interpersonal and social factors. Serious violence was associated with psychotic and depressive symptoms, childhood conduct problems, and victimization.

Since schizophrenia is life-long, usually beginning in teenage years in males and a bit later in females, the total period of exposure to the risk of violent behavior is high. Treatment with modern drugs reduces this considerably but most schizophrenics who are not under good supervision do not take their drugs.

The mother of the shooter was the registered owner of three guns, two of them pistols and one a “bushmaster” rifle. These are military lookalikes that are mostly in 5.56 NATO round calibres. They are also very expensive rifles. The rifle found in the shooter’s care was described as .223 calibre and the Bushmaster site does not include any of this calibre. UPDATE: I did not recognize the .223 as the same calibre as the 5.56 NATO round. It is the same. The .223 is in inches and 5.56 is millimeters. A momentary lapse.

He did not use the rifle anyway but what was the mother doing buying this for her autistic son? Pistols might have been for her own protection but the rifle doesn’t make sense except as evidence of enabling behavior by the mother.

I will add to this post as more information comes out. This looks to me like an incident of mass violence by a schizophrenic 20 year-old male with possible assistance by his mother in allowing him access to guns.

The mother is now being described as a “survivalist” and used to target shooting. That does not explain why she had guns around her psychotic son. “Autism” does not develop during teenage years. It is a phenomenon that is recognized in infancy. The term may have been used by the older brother as it is a less “disreputable” term for schizophrenia. If this represents a form of denial by the family, it may be significant.

Bioengineering is coming fast.

Tuesday, October 30th, 2012

An interesting article from bbc explains how concrete treated with a species of bacillus can “heal concrete” cracks by making more limestone.

Experimental concrete that patches up cracks by itself is to undergo outdoor testing.

The concrete contains limestone-producing bacteria, which are activated by corrosive rainwater working its way into the structure.

The new material could potentially increase the service life of the concrete – with considerable cost savings as a result.

The work is taking place at Delft Technical University, the Netherlands.

It is the brainchild of microbiologist Henk Jonkers and concrete technologist Eric Schlangen.

If all goes well, Dr Jonkers says they could start the process of commercialising the system in 2-3 years.

From the article, it sounds like these are not engineered bacteria but engineering may increase yield.

“Micro-cracks” are an expected part of the hardening process and do not directly cause strength loss. Fractures with a width of about 0.2mm are allowed under norms used by the concrete industry.

But over time, water – along with aggressive chemicals in it – gets into these cracks and corrodes the concrete.

“For durability reasons – in order to improve the service life of the construction – it is important to get these micro-cracks healed,” Dr Jonkers told BBC News.

Bacterial spores and the nutrients they will need to feed on are added as granules into the concrete mix. But water is the missing ingredient required for the microbes to grow. Concrete is the world’s most popular building material, but cracking is a problem

So the spores remain dormant until rainwater works its way into the cracks and activates them. The harmless bacteria – belonging to the Bacillus genus – then feed on the nutrients to produce limestone.

The bacterial food incorporated into the healing agent is calcium lactate – a component of milk. The microbes used in the granules are able to tolerate the highly alkaline environment of the concrete.

The cost will be high per unit but in the overall scheme of things, reduction in maintenance and longer functional life will dwarf cost issues.

Far out there.

Saturday, October 20th, 2012

Once again, Craig Venter is looking for new challenges. The latest may be Martian DNA.

I have thought for some time that life on Mars is going to consist of microorganisms and be buried several feet below the surface of the planet soil. I have even blogged about it before.

Now, there is a possibility of a nucleotide sequencer that could go to Mars on the next probe in 2018.

In what could become a race for the first extraterrestrial genome, researcher J. Craig Venter said Tuesday that his Maryland academic institute and his company, Synthetic Genomics, would develop a machine capable of sequencing and beaming back DNA data from the planet.

Separately, Jonathan Rothberg, founder of Ion Torrent, a DNA sequencing company, is collaborating on an effort to equip his company’s “Personal Genome Machine” for a similar task.

“We want to make sure an Ion Torrent goes to Mars,” Rothberg told Technology Review.

Although neither team yet has a berth on a Mars rocket, their plans reflect the belief that the simplest way to prove there is life on Mars is to send a DNA sequencing machine.

“There will be DNA life forms there,” Venter predicted Tuesday in New York, where he was speaking at the Wired Health Conference.

Venter said researchers working with him have already begun tests at a Mars-like site in the Mojave Desert. Their goal, he said, is to demonstrate a machine capable of autonomously isolating microbes from soil, sequencing their DNA, and then transmitting the information to a remote computer, as would be required on an unmanned Mars mission. Heather Kowalski, a spokeswoman for Venter, confirmed the existence of the project but said the prototype system was “not yet 100 percent robotic.”

Doing this on Mars would avoid the problem of contamination by earth organisms. New life forms that don’t use DNA might be a problem but most people who have thought about this believe that DNA is the genetic material of all life forms. Of course, protein, which may have been the original genetic material on earth could also be the Martian equivalent.

We are starting to see commercial spacecraft develop and one was used to reach the international space station recently. A Mars mission is another order of complexity but by 2018, it may be an option.

UPDATE: A new report describes obtaining natural gas (methane) from coal using bacteria or archea.

Many coal beds contain large amounts of methane that can be harvested by drilling wells. In recent decades, researchers have demonstrated that a large fraction of the natural gas found in the coal beds is produced by naturally occurring microörganisms that feed on coal, and they have found ways to stimulate the microbes to produce more methane. Luca Technologies, based in Golden, Colorado, is using this approach to increase production from coal beds with existing methane wells. Another company, Next Fuel, based in Sheridan, Wyoming, recently showed that it could use similar technology to produce methane from coal beds that didn’t already have methane in them, raising the possibility that vast amounts of coal that’s currently too expensive to mine could be converted into natural gas.

What will we find on Mars that might be an analogous system ?

Craig Venter and biofuels

Monday, October 15th, 2012

Biofuels have gotten somewhat of a bad rep with conservatives because they are linked to Obama’s green energy boondoggles. Steve Hayward, at Powerline, thinks that success will be enough to turn the greenies against them. First they will be genetically engineered and will be developed by “Big Oil” partnering with entrepreneurs like Craig Venter who deciphered the human genome with private resources. He was in competition with the government funded “Human Genome Project.” My book review of Venter’s autobiography is here.

Venter does well in explaining his research and the article follows it well.

Venter said in an interview, “It’s pretty obvious that there’s nothing in the natural world to make the levels that are needed,” and he pointed to algae oil yield volumes needing approximately 20,000 gallons per acre equivalent of algae.

Venter and his research team, of course, in spring 2010, successfully created the first synthetic bacterial cell, which was controlled completely by a synthetic genome. Or as Venter explained it in his recent interview, as the first cell “to have a computer for a parent,” or “designed DNA on a living system.” Venter now says he has increasingly realized that a fully synthetic cell is the way to go to create competitive algae fuel. When it comes to tweaking naturally occurring algae cells, he says, “you’ll never get there with that. We need a fundamental change to how we approach all this.”

This will be enough to antagonize the Luddite Greenies who are ideologically hostile to genetic engineering. Some writers are already predicting problems.

Venter, the first mapper of the human genome and creator of the first synthetic cell (pictured above), said his scientific team and ExxonMobil have failed to find naturally occurring algae strains that can be converted into a commercial-scale biofuel. ExxonMobil and Venter’s La Jolla, Ca.-based Synthetic Genomics Inc., or SGI, continue to attempt to manipulate natural algae, but he said he already sees the answer elsewhere — in the creation of a man-made strain. “I believe that a fully synthetic cell approach will be the best way to get to a truly disruptive change,” Venter told me in an email exchange.

Venter made his remarks before a conference this week on the future of energy at the New America Foundation in Washington, D.C., and in subsequent emailed replies to questions.

When announced in July 2009, the Venter-ExxonMobil alliance of colossals attracted wide publicity. It called for ExxonMobil to spend up to $600 million if publicly undisclosed milestones were reached in the lab. The Wall Street Journal said the partnership might signal “a coming of age” for algae biofuel. Greenbang fretted that the alliance might actually prove “unholy,” but not Gigaom, which said it could be “algae’s big break.”

The terms of the alliance omit the fully synthetic approach that Venter is now advocating, so he is conducting “an ongoing dialog” with Exxon about a new agreement, he said. He appeared to suggest that such a new compact would require more Exxon investment.

If I were in charge of investing in alternate energy research, I would take what Venter says very seriously.

I assume that our skill set in this area has been one of the attractions for Exxon to work with us. Our success at building the first synthetic cell is only from last year and had not been achieved when we formed the agreement between SGI and Exxon. So I would say it is an ongoing dialog.

The future lies with algae and modifications of coal. Ethanol is a dead end. Venter is not the only one interested.

One of the dangers of using the synthetic algae cells is the fear that the cells could somehow be let loose on the outside world, which Venter admits could wreak havoc like turning the oceans into a sea of lipids. But Venter says that designing an organism that has self-destructive properties (it can’t live outside a lab, or it dies with a certain time period) could contain such an organism.

Algae oil company Solazyme, went public this year, and plans to commercialize its algae fuel in the coming years. Solazyme tweaks existing efficient algal strains and grows its designer algae in fermentation tanks without sunlight by feeding it sugar and then using existing industrial equipment extracts the oil. Solazyme’s stock is trading a bit under $10, way down from its IPO price of $18.

I would bet on Venter, first of all because he thinks in terms of private, profit making business. His record is pretty impressive and he has hired a lot of the world’s experienced scientists. I have previously written a number of blog posts on related topics, here, and here, and here, and here.

It’s interesting that the Titanic is being eaten by “Rusticles” that that are eating the iron in the hull. Bacteria that eat iron in an oxygen-free environment are only one of the marvels that are being discovered in the depths of the ocean and in hot vents in volcanic pools.

Decision theory

Sunday, July 8th, 2012

About 17 years ago, I spent a year at Dartmouth Medical School getting another degree in medical outcomes research. I had retired from the practice of surgery after a 14 hour spine fusion. In college, I had a fall in gymnastics class that sent me to the student health center. They x-rayed my neck but not my back below the neck. When I began medical school, we all had to have chest x-rays and mine showed that the fall had caused a three level compression fracture in my thoracic spine. After 18 years in practice and 25 years of standing at an operating table, I had begun to have trouble with my back. It began with pain but continued to signs of spinal cord compression. In 1994, I went to UC San Francisco to consult David Bradford, who had written a number of papers on newer techniques in the surgery I needed. He agreed that I needed it and we arranged for me to have the surgery after Christmas 1994. It involved a lengthy recovery so I retired from my practice and turned it over to a younger associate. I had planned to return part time and see office patients only but he had other ideas, which were not well thought out but there was little I could do about it.

I had been interested in medical quality measurement for years. Now, with no activity planned once I recovered, I got interested in the Dartmouth program. It was called “Center for Evaluative Clinical Sciences,” a rather clumsy name. It is now called something else, but the idea is the same. Jim Weinstein, who is now CEO of the Dartmouth-Hitchcock medical center, was in my class that began in 1994.

The program included some remedial math for us oldsters. Although I had been an engineer it had been in the 1950s. We got a lot of statistics education and some health policy. The Dartmouth folks had been involved in the design of Hillary Clinton’s health plan and I had some fundamental disagreements about policy with them. Like so many academics, they were convinced that they knew how to run a top-down system and I was not so sure. However, the methodology training was, I thought, to be invaluable to me.

Two new areas, in my own experience, were very enlightening. One was survey design, in which I learned a lot about surveys, and incidentally, about polling. The other was decision theory. I had had no idea how important this was to be in health care.

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Global Warming and acupuncture

Thursday, June 16th, 2011

It looks as though the sun is entering a new dormant period, similar to the Maunder Minimum which led to the Little Ice Age.

This will almost certainly end the global warming hysteria in a few years. The people who continue to cling to this sort of hoax, will be looking for the Next Big Thing. I don’t mean to imply that the earth did not warm over the past century. The Little Ice Age ended about 1850 so a warming trend is expected following such an event. The hoax is the contrived evidence that humans are responsible. I was skeptical about that from the first. The forces involved are too large. If humans affected climate, it probably began with the development of agriculture. Perhaps we have had no ice age in the past 10,000 years because of the effects of agriculture and forest changes. I have previously discussed this and nothing has changed my mind.

The next question is what will replace global warming as the religion of the bored classes ? There are signs that it may be “New Age” medicine. This sort of thing is common in certain circles and has considerable similarity to the global warming arguments.

The Center for Integrative Medicine, Berman’s clinic, is focused on alternative medicine, sometimes known as “complementary” or “holistic” medicine. There’s no official list of what alternative medicine actually comprises, but treatments falling under the umbrella typically include acupuncture, homeopathy (the administration of a glass of water supposedly containing the undetectable remnants of various semi-toxic substances), chiropractic, herbal medicine, Reiki (“laying on of hands,” or “energy therapy”), meditation (now often called “mindfulness”), massage, aromatherapy, hypnosis, Ayurveda (a traditional medical practice originating in India), and several other treatments not normally prescribed by mainstream doctors. The term integrative medicine refers to the conjunction of these practices with mainstream medical care.

Here we have what may become the replacement for AGW in the minds of the exquisite privileged class. It has all the requirements.
1. America is corrupt and inferior ? Yes.
2. Capitalism is corrupt and inferior ? Yes
3. Only the truly intelligent and sensitive can appreciate it ? Well.

You might think the weight of the clinical evidence would close the case on alternative medicine, at least in the eyes of mainstream physicians and scientists who aren’t in a position to make a buck on it. Yet many extremely well-credentialed scientists and physicians with no skin in the game take issue with the black-and-white view espoused by Salzberg and other critics. And on balance, the medical community seems to be growing more open to alternative medicine’s possibilities, not less.

That’s in large part because mainstream medicine itself is failing. “Modern medicine was formed around successes in fighting infectious disease,” says Elizabeth Blackburn, a biologist at the University of California at San Francisco and a Nobel laureate. “Infectious agents were the big sources of disease and mortality, up until the last century. We could find out what the agent was in a sick patient and attack the agent medically.” To a large degree, the medical infrastructure we have today was designed with infectious agents in mind. Physician training and practices, hospitals, the pharmaceutical industry, and health insurance all were built around the model of running tests on sick patients to determine which drug or surgical procedure would best deal with some discrete offending agent. The system works very well for that original purpose, against even the most challenging of these agents—as the taming of the AIDS virus attests.

But medicine’s triumph over infectious disease brought to the fore the so-called chronic, complex diseases—heart disease, cancer, diabetes, Alzheimer’s, and other illnesses without a clear causal agent. Now that we live longer, these typically late-developing diseases have become by far our biggest killers. Heart disease, prostate cancer, breast cancer, diabetes, obesity, and other chronic diseases now account for three-quarters of our health-care spending. “We face an entirely different set of big medical challenges today,” says Blackburn. “But we haven’t rethought the way we fight illness.” That is, the medical establishment still waits for us to develop some sign of one of these illnesses, then seeks to treat us with drugs and surgery.

A science blog states the case for scientific medicine.

Speaking of bad ideas, in contrast to his previous article, in which he managed at least to get the gist of what Ioannidis teaches but merely spun it in what I considered to be an annoying fashion, the entire idea behind Freedman’s new article channels the worst fallacies of apologists for alternative medicine. The whole idea behind the article appears to be that, even if most of alternative medicine is quackery (which it is, by the way), it’s making patients better because its practitioners take the time to talk to patients and doctors do not. In other words, it’s a massive “What’s the harm?” argument. Yes, that’s basically the entire idea of the article boiled down into a couple of sentences. Deepak Chopra couldn’t have said it better. Tacked on to that bad idea is a massive argumentum ad populum that portrays alternative medicine (or, as purveyors of quackademic medicine like to call it, “complementary and alternative medicine” or “integrative medicine”) as the wave of the future, a wave that’s washing over medicine and teaching us cold, reductionistic doctors to care again about patients and thus make them better. Freedman even contrasts this to what he calls the “failure” of scientific medicine. I kid you not. Worse, Freedman makes this argument after having actually interviewed some prominent skeptics, including Steve Salzberg and Steve Novella, in essence, missing the point.

I expect to see more and more of “alternative medicine” because it appeals to the science illiterate and it damns another traditional source of authority, scientific medicine. Global warming hysteria attacks capitalism and prosperity. Alternative medicine is also going to be useful to Obamacare as a way of cutting reimbursement for traditional care. That will be a powerful wind behind it.

What a tsunami looks like

Sunday, March 13th, 2011

This video, from Al Jazerra of all places, shows what a tsunami looks like;

The movie, Hereafter, does an excellent job of simulating the tsunami that hit Thailand two years ago. No one, I suspect, thought they would have another real example soon.

The coming energy crisis

Friday, January 14th, 2011

The Obama administration is still in the throes of global warming mentality. They have cancelled leases for oil and gas in the huge deposits in western states like Montana. The vast boom going on just to the north in Alberta has not impressed Interior Secretary Salazar. They want to take millions of acres out of the energy search by naming them wilderness, just as Bill Clinton created a huge wilderness area out of good potential energy fields at the end of his administration. They have not made nuclear power plants any easier to build. The Gulf oil leases are still blocked and the moratorium, while allegedly ended, continues in a slow down. The only energy and his acolytes are interested in is “renewable” such as wind and sun. These are boutique power sources and even these are being blocked by Democratic politicians.

But the project is hardly shovel ready. Several regulatory hurdles remain, and opponents of the wind farm have vowed to go to court, potentially stalling Cape Wind for several more years.

For years the Cape Wind project has been the focusof pitched battles splitting politicians and environmental groups. While some environmentalists are prepared to go to court to stop the project, other major groups, including the Sierra Club and Greenpeace, support it.

Senator Edward M. Kennedy of Massachusetts, whose family compound overlooks Nantucket Sound and who died last year, had opposed the project, saying it was a giveaway to a private developer.

It has taken nine years to get this far. In California, another lefty state, a big solar project is being fought by enviros and Democrats. I wonder if the left wants any energy developed. It seems insane but we are getting very close to a tipping point when there will not be time to build new projects and find more oil and gas.

The Democrats, and the vast array of “activists” whom they enable, have demonstrated hostility to all practical forms of energy production and distribution. This is not just a matter of oil & gas drilling: as we have discussed many times on this blog, the U.S. electrical system faces a problematic future. There is every likelihood that, under a Democratic administration/Congress:

a)The building of new coal plants would go from “difficult” to “impossible”
b)The building of nuclear plants would continue to be virtually impossible
c)Even the building of new natural-gas-fired plants would be severely delayed by environmental lawsuits and regulatory maneuvering based on the CO2-is-a-pollutant theory.

Solar and wind, beloved of Democrats, have their uses, but they also have their limitations. I see no evidence that either Obama or the Dem Congressional leadership has any interest in understanding the technical and economic factors that govern the extent to which these technologies can be practically employed. The intermittent nature of wind and usable sun, the difficulty of storing electricity, the supply-chain constraints which govern the large-scale introduction of any new technology–there is much less interest in these things than in the glib repetition of catch-phrases. And even the use of environmentally-blessed technologies will be greatly inhibited by environmentalist protests against the transmission lines required to connect these systems to the cities that need their power. These activists would, of course, gain great impetus from a Democratic administration.

Obama talks a lot about the middle class. The existence of a large and affluent middle class is enabled by widely available and reasonably priced energy, especially electricity. If electric rates are driven up by a factor of 2X or 3X, as is entirely possible with Democratic policies, there will be not only a direct effect on consumers, but an effect on virtually all workers as U.S. businesses–especially manufacturing businesses but also things like data centers–become less competitive.

Lenin once remarked that “Communism is Soviet power plus electrification.” Our present “progressives” seem more interested in de-electrification. Where the New Deal (and the Soviets) wanted to build hydroelectric dams, today’s “progressives” are, for the most part, more interested in destroying them.

Remember, electrical infrastructure is a long-leadtime item, and if we dig outselves into a deep hole in this matter, it will take a long, long time to dig ourselves out..

That was written in 2008. Read the whole thing. It did a pretty good job of predicting the Obama administration’s policies.